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  Example (1) Dynamic observation of NOAAs in liquid

   
   Dynamic observation of silicate nanoparticles in water
 
      
   
   Dynamic observation of polystyrene beads under various media
 
  



  Example (2) Gold nanoparticles (AuNP) in rat blood

       ( Anal. Chem. 2012, 84: 6312 −6316 )
 

K-kits allow direct observation of nanoparticles in blood. Simply place K-kit channel in contact with whole blood sample without any pretreatment, serum will be loaded into the channel by capillary effect.
 
 

 
Image-based statistic analysis of Particle Concentration  (K-kit vs. ICP-MS)

 

Image-based statistic analysis of aggregation and agglomeration of AuNPs in blood
 


  Example (3) CaCO3 nanoparticle additive in milk

  • Comprehensive physicochemical characterization

For liquid food and food supplements, K-kits allow direct observation of nanoscale objects in final product form.
 
  • Size and size distribution of CaCO3 NOAAs in milk  

The statistical analysis of CaCO3 nanoparticles in milk.
 
 

  Example (4) Zinc Oxide nanoparticles in sun screen lotion
K-kit can be used for characterizing NOAAs in cosmetics in final product forms, including lotion, cream, and powder, to assess the safety risks of nanomaterials in cosmetic ingredients.


 
 Example (5) Protein particles in Nanopharmaceuticals
 
Protein particles (Paclitaxel@Albumin) in Abraxane®
 
   Abraxane in saline _ size & size distribution (D10/ D50/ D90)
 

K-kit can be used for characterizing protein particles in Nanopharmaceuticals by imaging the particle morphology, size and size distribution, to evaluate drug formulation or conduct any bioequivalence study. 
 


 Example (6) Micella in aqueous solution 



 
  Micelle
A micelle or micella (plural micelles or micellae, respectively) is an aggregate (or supramolecular assembly) of surfactant molecules dispersed in a liquid colloid. A typical micelle in aqueous solution forms an aggregate with the hydrophilic "head" regions in contact with surrounding solvent, sequestering the hydrophobic single-tail regions in the micelle centre. 
   
  • To evaluate the result of micelles in liquid by using K-kit (with liquid), compared with the conventional way by Cu grid (without liquid).
  • Test sample: Micelles solution with particle sizes of around 30-50nm
  • K-kit: Gap0.2um/ SiN100nm ones in wet mode 
  • TEM: Hitachi HT7700 @100KV 

In K-kit (Magn. x 10K)
On Cu grid (Magn. x 10K)
  • There’re many single-micelles that with the sizes of around 30nm spread uniformly and only a very few amounts of lumpy objects found in K-kit. 
  • By using K-kit, one may characterizes the micelle particles in liquid, without the drying effect to result in aggregates or agglomerates.  

In K-kit (Magn. x 20K)
On Cu grid (Magn. x 20K)
  • On Cu grid, most of the micelles aggregated due to drying effect and only a very few single-micelles remained sporadically. 
  • The sizes of those single-micelles, which observed of around 10nm, on Cu grid were much smaller than the ones in K-kit, due to the structure collapsed by drying.
K-kit can be used for characterizing micelle particles in liquid, by imaging the particle morphology, size and size distribution.