Micro and Nano Bio Medical Area

For nanomedicine, Bio MA-Tek adopts appropriate sample preparation protocols (such as vacuum-dried, negative staining, cryo, liquid (K-kit), ultramicrotome, etc) for different types of samples such as virus, vaccine, and nanoformulated agents, etc.  Comprehensive information of their physicochemical parameters can be obtained.

Direct observation in liqild
With advanced sample preparation techniques
● Liquid sample TEM (K-kit): A microchip-based holder to contain and seal liquid sample inside for direct TEM observation ● PLGA: poly (Lactic-co-glycolic Acid) ● Resovist®:  an iron oxide nanoparticle-based MRI contrast agent，(Ferucarbotran) ● MSNs: Mesoporous Silica Nanoparticles

TEM Image Analysis
(Example) Nanoformulation agents; Figure on the left shows gold nanoparticles distribution in cells, Figure on the right shows nanoparticle morphology.
(Example) Vaccine_ Figure on the left is the viral particle morphology; Figure on the right is the adjuvant.

 Application Example: A Doxorubicin Encapsulated Liposomes
 

Cryo-TEM	UA negative Stain
The images of the liposomes enclosed with drug of Adoxorubincin. (Original condition)
After an ultrasonic process at 37C for 2 hours, the liposomes were fractured to release the drug. (Leakage condition)
Counted # : original cond. by 403ea, leakage cond. by 225ea
The size/size distribution of liposome was counted and measured by cryo-TEM images.

Bio MA-Tek follows the international regulatory guidance and international standards to provide professional and high quality services on nano biomedical characterization/analysis.

Download

 Nano-pharmaceuticals (CH) 2017-09-04