|For nanomedicine, Bio MA-Tek adopts appropriate sample preparation protocols (such as vacuum-dried, negative staining, cryo, liquid (K-kit), ultramicrotome, etc) for different types of samples such as virus, vaccine, and nanoformulated agents, etc. Comprehensive information of their physicochemical parameters can be obtained.|
| Direct observation in liqild |
With advanced sample preparation techniques
● Liquid sample TEM (K-kit): A microchip-based holder to contain and seal liquid sample inside for direct TEM observation
● PLGA: poly (Lactic-co-glycolic Acid)
● Resovist®: an iron oxide nanoparticle-based MRI contrast agent，(Ferucarbotran)
● MSNs: Mesoporous Silica Nanoparticles
| TEM Image Analysis |
(Example) Nanoformulation agents; Figure on the left shows gold nanoparticles distribution in cells, Figure on the right shows nanoparticle morphology.
(Example) Vaccine_ Figure on the left is the viral particle morphology; Figure on the right is the adjuvant.
|Cryo-TEM||UA negative Stain|
The images of the liposomes enclosed with drug of Adoxorubincin. (Original condition)
After an ultrasonic process at 37C for 2 hours, the liposomes were fractured to release the drug. (Leakage condition)
Counted # : original cond. by 403ea, leakage cond. by 225ea
The size/size distribution of liposome was counted and measured by cryo-TEM images.
Bio MA-Tek follows the international regulatory guidance and international standards to provide professional and high quality services on nano biomedical characterization/analysis.